Pentobarbital will decrease the level or effect of budesonide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. When barbiturates like Nembutal are abused, they are not usually the primary drug of abuse. Like https://damienjlnno.thecomputerwiki.com/5722200/niet_bekend_feiten_over_nembutal_dosering_informatie